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In order to be taken up by the liver it has to be degraded to amino acids. [I also wonder- since glutamate is elevated in metabolic disease, and a residue in the GSH tripeptide, might it be that providing glycine or serine to support synthesis could be preferred over glutathione

Here, we show that sustained iron overload, but not acute exposure, leads to a state of ferroptotic stress where nerve cells remain viable but become hypersensitive to oxidative injury

Multiple tissues showed lower lipogenic enzyme expression, suggesting lipid production might also be impaired

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