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[] Furthermore, an investigation is required with more extensive clinical evidence to use therapeutically incretin-based medication including tirzepatide in neurological disease

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Together, this new class of drugs could lead to sales in the tens of billions of dollars in the upcoming years

G protein-coupled receptor kinases (GRKs) phosphorylate specific sites at the receptor C-terminal tail, providing binding sites for -arrestins (van Gastel et al., 2018)