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The findings indicate that microbial metabolite 4-ethylphenyl sulfate (4EPS) enters the brain and is associated with changes in region-specific activity and functional connectivity, including altered oligodendrocyte function, impaired oligodendrocyte maturation, and decreased oligodendrocyte-neuron interactions (Needham et al., 2022)

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Reduced folate/ThDP exchanger SLC19A1, demonstrating decreased transcript levels 1 month after the bypass, shares the cluster (3 g) with mitochondrial ThDP transporter SLC25A19, ThTPase and BCKDHA (Figure 5A)

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According to the NIH Office of Dietary Supplements, vitamin B12 is available as cyanocobalamin and hydroxocobalamin, which are typically administered parenterally by intramuscular injection to bypass gastrointestinal absorption barriers