In the SUSTAIN program, acute kidney failure was only reported in SUSTAIN 6, where its occurrence was similar between semaglutide and placebo ( In contrast to the incidental cases of AKI, the CVOTs mainly demonstrate a beneficial effect on renal outcomes, likely because of effects on cardiovascular risk factors (117)
doi: 10.1136/gut.38.6.916 23 RanganathLNorrisFMorganLWrightJMarksV
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Published research has characterized MT-1 as a potent and selective MC1R agonist, distinguishing it from broader melanocortin receptor agonists