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In rodents, those receptors are abundant on C-cells, and chronic GLP-1 stimulation drives the cells to proliferate
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The development of triple agonists (e.g., GLP-1/GIP/glucagon agonists like Retatrutide) or other multi-target agents (e.g., GLP-1/amylin/GIP) represents the next frontier in drug discovery (31)
Their primary function is to inhibit the conversion of angiotensin I to angiotensin II, leading to vasodilation and a reduction in blood pressure
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