why did my tirzepatide stop working Not Losing Weight on Tirzepatide? 7 Reasons Why Mounjaro Stops Working: Weight

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This is often shown in milligrams (mg) or micrograms (mcg)

Science 368 , 13711376 (2020)

GLP-1RAs work by increasing the levels of the hormone glucagon-like peptide-1 (GLP-1) in the body

Randomised withdrawal trials in this class consistently show substantial weight regain after discontinuation, and a 2026 review in EClinicalMedicine reports that roughly two-thirds of lost weight is typically regained within a year of stopping

Insulin facilitates the uptake of glucose by cells, thereby reducing blood sugar levels, while glucagon increases blood sugar levels by stimulating glucose production in the liver