Figure 1 4.1 Activation of Toll-like receptors by dysbiotic microbiome affects esophageal barrier structure, epithelial repair, and triggers inflammatory responses involved in GERD G- bacteria are key producers of lipopolysaccharide (LPS), which abnormally activates a variety of Toll-like receptors (TLRs) leading to epithelial barrier dysfunction and inflammatory responses leading to GERD
The lack of human safety data creates uncertainty, but uncertainty is not the same as known danger
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KK has received honoraria for lectures/advisory boards and research support from AstraZeneca, Boehringer Ingelheim, Pharmaserve Lilly, Sanofi-Aventis, ELPEN, MSD, and Novo Nordisk