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In this trial, 342 men with sildenafil-failure ED were given either intranasal PT-141 (10 mg dose) or placebo on demand over ~48 weeks.The outcomes demonstrated a clear benefit of bremelanotide: About 33.5% of men on bremelanotide achieved a positive clinical response (improved erections sufficient for intercourse) compared to only 8.5% on placebo

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

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Keep a watchful eye on methionine adenosyltransferases, novel therapeutic opportunities for hepatobiliary and pancreatic tumours

Wald DS, Law M, Morris JK