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Furthermore, a recent extensive cohort study involving over 33,000 GLP-1 RA users diagnosed with diabetes over a 9-year period indicated no significant increase in pancreatic cancer risk associated with GLP-1 RA use, as evidenced by an HR of 0.50 compared to basal insulin [60]

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There are three major causes of migraine which are Vascular (due to cerebral vasodilatation), Ineurological (abnormal neurological firing which causes the spreading depression and migraine) and Neurogenic dural inflammation (release of inflammatory neuropeptides) In this combination, Magnesium plays an important role in mitochondrial energy production, and magnesium deficiency can lead to many physiological changes, including cerebral artery spasm and increased release of pain mediators

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