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In the SURMOUNT-1 phase-3 trial, tirzepatide produced dose-dependent weight loss reaching about ~21% of total body weight at the 15 mg dose, substantially more than placebo, with gastrointestinal symptoms the most common adverse events [6] [7]
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Once the existing microcomedones clear, many users find their skin is actually clearer than before they started
6.5 in the placebo group), suggesting a higher potential for improvement (i.e., decrease of migraine days)
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Some higher-dose formulations, like Wegovy and Saxenda, are FDA-approved for weight loss
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