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As with the skin work, the framing in published reviews remains observational with respect to mechanism, and most authors note that the in vivo translation outside of topical and injected animal-model contexts is not fully characterized

Most dogs do well with once-daily dosing, given consistently at the same time each day

10.1016/j.neubiorev.2018.05.005 56 JacksonL.EldahshanW.FaganS

(2) Endoplasmic Reticulum Stress: CS induces ER stress and activates the unfolded protein response (UPR)

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Only minor reactions have been reported by some patients, such as pain at the injection site