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Inhibiting related enzymes such as fatty acid desaturase 2 (FADS2) and acetyl-CoA carboxylase (ACC) confers resistance to lipid peroxidation and ferroptosis induced by the compound RSL3 [38, 39]
In incretin-based trials, early weeks are often dominated by titration and tolerability: nausea, diarrhea, constipation, vomiting, appetite changes, and satiety shifts
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