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An alternate possibility is that cytosolic NADPH manipulation ultimately affects matrix NADPH status through metabolite shuttles, which are used to convey reducing equivalents across the mitochondrial membranes by coupling mitochondrial redox reactions with their cytosolic counterparts (for example, using the transport of citrate to couple IDH2 and IDH1) (Taylor, 2017)

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The mechanism profile makes biological sense, the safety record appears favorable, and the practical results align with what the science would predict