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In the form of a biofilm treatment, it may be used to regulate the die-off reaction or Herx reaction that occurs during antimicrobial treatment for infections

When proliferating chondrocytes mature, they increase the production of Ihh, which acts on its receptor Patched in the neighboring cells via unknown mechanisms to increase the production of PTHrP (39), thus slowing down cell differentiation to prevent early closure of the growth plate (Figure 1)

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