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gastrointestinal side effects and dose-dependent tolerability issues were the most notable findings, and Phase 3 trials are needed before regulatory submission

Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness

By comparison, those taking Wegovy the highest-dose semaglutide formulation approved for weight loss lost up to 17.4% in a similar time period (68 weeks)

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Acknowledgements This study was supported by National Key Research and Development Plan Precision Medicine Research (2017YFSF090203), the National Natural Science Foundation of China (81470840, 81873565 and 81800510), Shanghai Sailing Program (18YF1415900), VA Merit Award (I01BX004033 and I01BX001390), and Research Career Scientist Award (IK6BX004477)