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Because it targets two metabolic pathways simultaneously, Tirzepatide is often referred to as a dual incretin receptor agonist
Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times
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134 , e175634 (2024)
The association of depression and anxiety with pain: a study from NESDA
McIntyre, A
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