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In this context, several sensors and pathways regulating the transcription factors, such as activator protein 1 (AP-1), cAMP response element-binding protein (CREB), hypoxia inducible factor-1 (HIF-1), nuclear factor B (NF-B), activating transcription factor 4 (ATF-4), and nuclear factor-erythroid 2-related factor-2 (Nrf2), have been described (Marinho et al
In addition to activating NRF2 by modifying Kelch-like ECH-associated protein 1 (KEAP1) thiols (Cys151), MMF also exerts undesirable off-target actions by indiscriminately modifying other protein thiols as well 3,4,5,6,7,8
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