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However, a very small number of peptides can have solubility or stability issues with benzyl alcohol
Sigma-Aldrich cytotoxicity assay kit) reduced 38 7% with GHK-Cu pre-treatment
doi: 10.3748/wjg.v11.i45.7078, 25
301 (1), G32G38
PMID 18758058
This gradual escalation prevents overwhelming side effects like flushing, nausea, or headaches that occur when starting at high doses, allows the pituitary to adapt to regular stimulation improving long-term response, and provides opportunity to identify minimal effective dose avoiding unnecessary higher dosing and associated costs
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