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This selective activity may support chondrocyte function and extracellular matrix synthesis while avoiding the complications associated with systemic growth hormone elevation

Hyperhomocysteinemia decreases GSH peroxidase activity leading to the prevalence of GSSG on GSH with the GSH/GSSG impaired ratio causing some common cardiovascular and neurodegenerative disorders (159)

The inherent physicochemical duality of PROTACs, possessing both hydrophilic and hydrophobic regions, complicates their efficient loading and stable encapsulation

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