In an in vitro model of Erastin-induced ferroptosis in PC12 neuronal cells, the iron inhibitor curcuminpolydopamine nanoparticles (Cur-PDA NPs) markedly enhanced the chelation of Fe 3+ and Fe 2+ , upregulated superoxide dismutase (SOD) and GSH expression, reduced Fe 2+ and ROS levels, inhibited lipid peroxidation, restored mitochondrial function, and attenuated neuronal ferroptosis
Neurology 95, e1267e1284
This is often a sign that the body is diverting a massive amount of energy toward tissue repair
2021, doi: 10.1021/acs.jmedchem.1c00565
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Methylcobalamin is often preferred due to its higher bioavailability and direct usability