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We quantified ~20,000 phosphopeptides across the 62 conditions in triplicates and performed ANOVA significance analysis on the log-transformed normalized intensities, which identified 1275 phosphorylation sites that were regulated in at least one condition (Supplementary Data 6)

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If there is a shortage of these, glutathione production will be lower

"Accutane-exposed pregnancies--California, 1999" (PDF)