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Participants were included if they were 18 years of age or older, had a BMI of 30 or higher (or 27 with at least one obesity-related complication), and reported at least one unsuccessful dietary effort for weight loss
Bibcode:1995NaGen..11..376L
Aim for 79 hours of quality rest each night
[61] noted that tirzepatide showed a significant reduction in body fat mass and adipocyte size, and improved insulin sensitivity
In the SUSTAIN 6 CV outcomes trial (CVOT), once-weekly semaglutide (0.5 or 1.0 mg) added to standard of care significantly reduced the occurrence of a first major adverse CV event (MACE: CV death, nonfatal myocardial infarction [MI], or nonfatal stroke) vs placebo over 2 years in 3297 subjects with T2D and high CV risk [12]
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