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Lack of sleep: When you don't get enough sleep, your body produces more ghrelin and less leptin, leading to increased appetite and cravings, especially for high-calorie, high-carb foods Chronic stress: Stress increases the hormone cortisol, which can also drive up appetite and lead to cravings for "comfort food." High cortisol levels can also disrupt your sleep, leading to more food cravings Even with semaglutide working in the background, a sleepless night or a stressful week can create hormonal shifts that are powerful enough to make you feel hungry

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Additionally, lifestyle interventions such as regular physical activity of minimum 150 min per week and pharmacological approaches as discussed in this review could further alleviate TMAO-related complications