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Under these conditions, the increased secretion of counterregulatory hormones stimulates FFAs oxidation in the liver and accelerates the production of ketone bodies, which are metabolized in muscle, adipose tissue and, most importantly, in heart and brain ( As demonstrated in a recent meta-analysis, SGLT-2i treatment is associated with increased plasma fasting glucagon levels in patients with diabetes compared with non-SGLT-2i treatments with a reduction of insulin and increased ketone body levels (91)

Ameliorative effect of spinach on non-alcoholic fatty liver disease induced in rats by a high-fat diet

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The mechanism of SELENOP intracellular turnover is not fully clear