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Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events

[1] If you are already taking B12 supplements, inform your doctor, as this may affect test interpretation

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Others might switch to an equivalent high-quality oral B-complex once their gut can absorb again