It points to receptor expression and metabolic markers such as fasting glucose and insulin sensitivity as influences on the therapeutic window
Neurochem Int 43 : 493499
Intensive studies are still required to unravel the crosstalk between different NRF2-regulated metabolic pathways and diseases and enable the development of a better strategy for combating human diseases

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Collectively, all GLP-1 receptor agonists, including native GLP-1, peptides, and small molecule GLP-1 receptor agonists, stabilize the binding pocket of the GLP-1 receptor in a similar fashion, which induces the TM helices 6 kink, a distinctive feature of the active state of the class B1 GPCR