According to the company, tirzepatide achieved a mean AHI reduction of up to 63%, meaningfully improving symptoms in those with moderate-to-severe OSA and obesity with and without positive airway pressure (PAP) therapy
in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )
Both compounds gastrointestinal effects are dose-related and both trial programmes titrate slowly for that reason, so pairing them stacks an effect that no monitored study has characterised
The semaglutide withdrawal symptoms guide discusses what happens when GLP-1 agonist levels fluctuate, and similar principles apply to retatrutide
The goal isnt just to lose weight
Astrup A, Carraro R, Finer N, et al