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I was familiar with Ozempic after hearing stories through friends, but my doctor recommended a different type of weight-loss drug, Mounjaro, since she had seen major weight loss success in patients with PCOS

The compound activates the GIP receptor (glucose-dependent insulinotropic polypeptide), the GLP-1 receptor (glucagon-like peptide-1), and the glucagon receptor simultaneously [1]

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Retatrutide activates three metabolic receptors at the same time: GLP-1, GIP, and glucagon

This shorter duration is actually advantageous for combination protocols, as it allows multiple daily administrations that can recreate pulsatile GH patterns more closely approximating physiological secretion when paired with the similarly short-acting Ipamorelin