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Direct contact can damage the amino acids that form the compound

Your mood and focus improve and anxiety decreases as your B12 levels increase

A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema

J Neurochem 102:170178 Kiskinis E, Sandoe J, Williams LA et al (2014) Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1

Nature 426 , 517524 (2003)