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Starting at the lower end allows assessment of individual tolerance before increasing if needed
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baseline mean problem score 14, dropping to 6 at week 12, rising to 9 two weeks post CyA discontinuation
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This is why the distinction between broadly activating the pathway and specifically disrupting an inhibitory interaction matters: removing a specific negative regulator that is overexpressed in a particular tissue is mechanistically different from constitutively switching the pathway on
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