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USAGE Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL

Acute recovery or loading phases may require weekly sessions for 46 weeks

IF Staining of mouse liver using 66323-2-Ig Immunofluorescent analysis of (4% PFA) fixed frozen OCT-embedded mouse liver tissue using 66323-2-Ig (Glutamine Synthetase antibody) at dilution of 1:400 and CoraLite488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L)

This was due to the presence of autoantibodies against folate receptor which blocked the folate binding site

Structural research further supports the idea that Retatrutides receptor engagement depends on both conserved receptor interactions and receptor-specific molecular contacts

7 At the higher 7.2 mg dose, approved for weight management in people with obesity, the STEP UP trial reported an average weight loss of 20.7% over 72 weeks