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Additionally, the SARS-CoV-2 nucleocapsid (N) protein physically binds Smad3 to promote its phosphorylation and nuclear translocation, thereby triggering the Smad3-RIPK3-MLKL pathway to induce severe tubular necroptosis and kidney injury in diabetic models (138)
Chen J, Wang D, Wang F, Shi S, Chen Y, Yang B, Tang Y, Huang C
Gribnau A, van Zuylen ML, Coles JP, Plummer MP, Hermanns H, Hermanides J
A cutoff value of 10.2 nmol/mg for GSH was identified, and the area under the ROC curve was 0.913, with a sensitivity of 90.2% and a specificity of 81.8%, demonstrating significant predictive capability in differentiating between the resistant group and sensitive group
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