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At the end of the trial, the colchicine group did not demonstrate objective improvement in penile curvature or plaque size

In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

Since it contains retinol, which can cause skin to be more sensitive to UV exposure, I keep this serum in my nighttime routine only

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Treatment decisions are based on individual clinical assessment