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It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood
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The longevity dividend Guheen and Baisley, however, see a silver lining among the clouds
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