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Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes

Heres a simple breakdown Ozempic (Semaglutide) Class: GLP-1 receptor agonist Helps: Control blood sugar + reduce CV risk Weight loss: Significant (~15%) Once weekly injection Common effects: Nausea, vomiting, diarrhea Extra: Proven cardiovascular benefit in T2D Trulicity (Dulaglutide) Class: GLP-1 receptor agonist Helps: Blood sugar control + CV protection Approved for children 10+ with T2D Weight loss: Modest Once weekly prefilled pen Common effects: GI discomfort Mounjaro (Tirzepatide) Class: Dual GIP + GLP-1 receptor agonist Helps: Powerful glucose control Weight loss: Highest among the three Once weekly (dose escalation) Common effects: GI symptoms (especially during dose increase) All carry a warning for possible thyroid C-cell tumor risk (avoid in patients with MEN2 or medullary thyroid carcinoma history)

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McCoin CS, Knotts TA, Ono-Moore KD, Oort PJ, Adams SH