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Amgen's MariTide, which combines GLP-1 agonism with GIP antagonism, was specifically designed based on genetic evidence suggesting this combination could reduce nausea while maintaining weight loss efficacy [44]
A few GLP-1 agonists currently in phase 3 trials are higher-dose injectable semaglutide 7.2 mg (Novo Nordisk), oral semaglutide 50 mg (Novo Nordisk) and orforglipron (Eli Lilly)
GHK-Cu should be avoided during pregnancy or breastfeeding, in active cancer or untreated solid tumors, in Wilson's disease or other copper-handling disorders, and in known copper allergy
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