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The AOD-9604 fragment takes a fundamentally different approach by isolating the lipolytic fragment of GH (amino acids 177-191) without its growth-promoting or IGF-1-elevating effects

10.1038/s41417-020-0182-y 144 LouandreC.EzzoukhryZ.GodinC.BarbareJ.-C.MazireJ.-C.ChauffertB.et al (2013)

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Higher body weight is considered to be among the risk factors for developing HS, though the causes are not fully understood, so its possible that in these patients the weight reduction was what alleviated their symptoms