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The drug remains in active clinical development, with Phase 3 trials currently underway evaluating retatrutide's efficacy and safety across broader populations, including individuals with obesity, type 2 diabetes, and cardiovascular disease
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USA 118 , e2101708118 (2021)
GLP-1 medications like semaglutide and tirzepatide mimic naturally occurring gut hormones that regulate appetite, slow gastric emptying, and improve blood sugar control
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Furthermore, bile acids can induce hepatocyte apoptosis by enhancing the localization of death receptors to the plasma membrane [38]
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