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The results showed a significant increase in skin density and thickness, with a 67% reduction in wrinkle volume and improved elasticity, as measured by ultrasound and profilometry (Leyden et al., 2002)

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This suggests a direct benefit in terms of abdominal fat reduction, which is often linked to improved heart health

However, the heterogeneity of CKD may obscure disease-specific drug effects, underrepresent Alport patients, and delay the discovery of targeted therapies

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