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Supplements for healthy estrogen metabolism include: SAMe, 5-MTHF, B12 (methylcobalamin), DIM, and NAC (or glutathione)
In a nutshell it takes away pigment
The inflammatory state associated with excess weight creates an environment where skin conditions flourish, as adipose tissue releases pro-inflammatory cytokines that trigger autoimmune responses
According to the NIH Office of Dietary Supplements, vitamin B12 is available as cyanocobalamin and hydroxocobalamin, which are typically administered parenterally by intramuscular injection to bypass gastrointestinal absorption barriers
PMID 20225319
Fun fact Glutathione levels naturally decline by up to 10% per decade after age 20
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