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Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011

Gut microbiota-derived metabolites, include TMAO, SCFAs, polyphenols, and bile acids, are essential for maintaining the healthy function of cardiovascular organs ( 3 Gut microbiota-induced mechanisms for cardiovascular disease Distinct gut dysbiosis profiles are closely associated with specific CVD subtypes, reflecting the complex interplay between microbiota composition and disease pathophysiology ( Akkermansia and Bifidobacterium , two genera known for their roles in maintaining metabolic homeostasis and gut barrier integrity

10.1080/08923973.2019.1569049 104 WangJ.LuoW.LiB.LvJ.KeX.GeD.et al (2018)

Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers