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In one study of 208 patients, 45 experienced 88 fractures, with Standardized Incidence Ratios (SIRs) of 2.9 in females and 3.4 in males

Washington D.C.: National Academy Press

These are usually mild, but some people feel them more than others

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The meetings are typically a forum for debate over products that have raised questions for FDA reviewers, and the agency historically has almost always accepted the advice of the experts