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Although lifestyle changes are the first line of treatment for obesity, even the most rigorous lifestyle changes typically only produce a 510% weight loss and maintaining weight over time is difficult due to compensatory physiological processes that increase appetite and decrease energy expenditure [134]
Diabetes Care 29, 471
To mitigate the limitations of existing Parkinson's disease medications, such as levodopa-induced dyskinesias, new compounds are being developed or are in the early stages of clinical trials to influence disease progression
[7] Lauterburg, B.H., Adams, J.D
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