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Cisplatin is a commonly used drug for treating osteosarcoma, but osteosarcoma cells can develop resistance to it, which reduces its therapeutic effect (190)
The authors reasoned that the regulation of GPX4 protein translation might involve amino acid-sensing mechanisms such as mTORC1 signaling
One procedure for purifying it involves treatment with a hot sulfuric acid solution, which denatures and partially decomposes most proteins other than ribonuclease A
Starting at the lower end of dosing ranges (20-30 mcg) and assessing response before increasing is advisable
Generally, the outlook for oral melanoma is poor
Gilmore LA, Klempel-Donchenko M, Redman LM
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