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Second, the emerging science on mitochondrial-derived peptides like MOTS-c suggests that our understanding of endurance biology is about to undergo a fundamental expansionone likely to yield new biomarkers, training-response models, and eventually therapeutic options

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For instance, a 12-month randomized controlled trial involving older adults (ages 60 to 81) demonstrated a 1.1-kilogram increase in fat-free mass with ibutamoren compared to placebo (14)