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Incidence of pancreatitis and pancreatic cancer in a randomized controlled multicenter trial (SAVOR-TIMI 53) of the dipeptidyl peptidase-4 inhibitor saxagliptin
Weight loss becomes more complex when autoimmune thyroid disease is present, and GLP-1 receptor agonists like semaglutide demand special consideration
For broader troubleshooting, see why you might not be losing weight on semaglutide
they don't replace it
Peaks 24-48 hours after injection
Interestingly, nonfatal heart attack showed the largest risk reduction among the three primary outcome components, contrasting with the earlier PIONEER 6 trial where cardiovascular death was the dominant benefitlikely because SOUL's longer follow-up and larger sample size (approximately three times that of PIONEER 6) allowed more comprehensive assessment of cardiovascular outcomes
