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More than half of participants on the 10 mg and 15 mg doses achieved 20% body weight loss, a threshold previously associated only with bariatric surgery

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It is worth emphasizing that Phase 2 data involves smaller sample sizes, and the full safety profile of retatrutide will become clearer as Phase 3 trials progress

Extracellular factors, such as metabolic shifts, microenvironmental controls, and the gut microbiota, also play critical roles in shaping these responses (Table 2)

The researchers looked to see whether this process was disrupted in the mice dying after treatment with the combination, finding increased numbers of autophagosomes (essentially recycling bins, containing cell proteins to be re-purposed), in the heart, liver and kidneys of the mice