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Specifically, beyond the enteroendocrine L-cells of the intestine, GLP-1 is also produced as a neuropeptide by the pre-proglucagon neurons in the brain stem 3
GLP-1 exerts its anorectic effect in part by acting on the hunger-satiety centre located in the arcuate nucleus of the hypothalamus, and in part by delaying gastric emptying
Fatigue on GLP-1 medications is typically caloric-restriction-related, not oxidative-stress-related
They are produced by different types of cells and, once released in the body, induce specific reactions in adjacent cells (paracrine effect), in others far away (endocrine effect) or in those that have created them (autocrine effect)
PubMed laboratory research record [PMID: 41768861] PubMed record related to this compound for laboratory literature review
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