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Verdict at a Glance Retatrutide demonstrated greater weight loss than survodutide in their respective Phase 2 trials (24.2% vs 18.7%), likely driven by its unique triple-agonist mechanism that adds GIP receptor activation

Semaglutide is best for a long-term solution that works with your weight loss journey as an incredible aid

Increased heart rate: Small increases in heart rate may be problematic for individuals with heart conditions such as atrial fibrillation or heart failure

Adverse Reactions Nausea, vomiting, abdominal cramps, diarrhea, and a "fishy" body odor can occur with doses of about 3 g/day

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Since weight loss is a primary treatment for IIH, and GLP-1 drugs promote weight loss, these medications are being studied as a possible treatment option for this condition