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In this context, carriers of apolipoprotein 4 (APOE4) allele, a major risk factor for AD, present with pericyte degeneration and associated BBB breakdown [42], which has been recently associated with cognitive decline, independent of AD pathology [43]

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10.1212/01.wnl.0000187070.35365.d7 Neurology 144 FerriA.CozzolinoM.CrosioC.NenciniM.CasciatiA.GrallaE

Surgical complications could include heart or bleeding problems, prolonged anesthesia effects, or increased blood pressure